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KMID : 0350519920450020557
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Journal of Catholic Medical College
1992 Volume.45 No. 2 p.557 ~ p.571
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Estrogen and Progesterone Receptors and Cell Proliferative Activities in Meningiomas
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Abstract
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It has been suggested thet hormonal manipulation may be proved to be an alternative mode of therapy, especially in cases of unresectable or recurrent meningiomas, and the effect of the endocrinological therapy may be influencedy by the presence
or
absence of hormone receptors in meninigiomas. The assessment of biological behavior of the tumors is important to plan postoperative adjuvant therapy and follow-up schedules, and the evaluation of cell proliferartive activities has been known to
be
valuable in prediction of recurrence and aggressiveness of meningiomas.
The purpose of this study was to investigate the status of hormone receptors and cell proliferative activities, and to determine the relationship between nucleolar organizer regions(AgNORs) and flow-cytometrio methods in evaluating cell kinetics
of
meningiomas.
Cytosolic estrogen receptors(ER) and progesterone receptors(PR) were studied in meninigiomas removed from 43 patients. Cell proliferative index(PI) based on tumor cell-cycle stage(%S+%G2M) was calculated by flow-cytometric studies of
paraffin-embedded
meningioma tissue blocks, and the mean number of AgNORs per cell was measured by silver-colloid staining techniques. Evaluable results of hormone receptors, PI, and AgNORs could be obtained in 40, 37, and 41 of original meningiomas, respectively.
Significant levels of ER(ER-1) was found in 27.5% of the patients, while significant PR levels (PR+) were detected in 40%. PR+were found in 14(40%) of 35 benign meninigiomas but in all of the one atypical and one malignant meningioma It appeared
that
the tumors with the anaplastic histological features of necrosis or brain infiltration had higher incidence of PR+ than the tumors without them, and the higher the cell proliferative activities, the higher the incidence of PR+.
PI of two atypical and one malignant meningiomas were rather higher but the number of AgNORs of them were significantly higher than those of thirty benign meningiomas(P<0.05). The tumors with the histological feature of mitotic figures had higher
proliferative activities than those without mitotic figures(P<0.05). Thirty-three percent of the benign meningiomas had the PI value higher than 30%, and about twelve percent of the benign meningimas had the AgNORs greater than 2.5 per cell. A
linear
correlation was demonstrated between PI and the number of AgNORs(r=0.71, P<0.001).
These results suggest that antiprogesterone therapy may be of use in treatment of highly proliferative or aggressive meningiomas, and the number of AgNORs showing correlation with PI may reflect the cell kinetics well and be of value in
predicting
recurrence of meningiomas and in planning postoperative adjuvant therapy.
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KEYWORD
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